Ketorolac Tromethamine (KT) is a non-steroidal agent with potent analgesic and moderate anti-inflammatory activity by inhibiting prostaglandin synthesis. The present work deals with the formulation and comparative evaluation of proniosomal and ethosomal gel of Ketorolac Tromethamine. The proniosomal gel was prepared by coacervation phase separation method by using different surfactants. The prepared proniosomal gel formulations were evaluated for vesicle size analysis, rate of spontaneity, entrapment efficiency, in-vitro release and in-vitro permeation study. The vesicle size of the proniosomes varied between 28.84 µm to 34.30 µm, rate of spontaneity between 2.0 mm3 × 1000 to 5.5 mm3 × 1000, % entrapment efficiency was in the range of 21.2% to 38.55%. In-vitro release profiles indicated that, increase in lipophilicity of surfactants decreases the release of Ketorolac Tromethamine. Among the various formulations studied, proniosomal gel with Tween 60 showed the highest % of drug release (80.35%) over a period of 12 hrs. The degree of in-vitro permeation across rat abdominal skin was found to be highest for the formulations P3 with 40.11% after 12 hours. Ethosomal gel formulations were prepared using varying concentrations of ethanol and lecithin. The prepared ethosomal gel formulations were evaluated for vesicle size analysis, entrapment efficiency, in-vitro release and in-vitro permeation study. Vesicle size of the ethosomes varied between 9.56 µm to 19.20 µm, % entrapment efficiency between 19.96% to 30.16%. Formulation E2 showed better in-vitro release profile with 45.46%. The degree of in-vitro permeation across rat abdominal skin was found to be highest for the formulations E1 which was 24.37% after 12 hours. Proniosomal gel formulations showed better entrapment efficiency, in-vitro release profile and permeation compared to ethosomal gel preparations.
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